美国药典标准品#1369442,环己亚硝尿相关化合物C,Lomustine Related Compound C (25 mg) (1,3-Dicyclohexylurea),CAS#2387-23-7


环己亚硝尿相关化合物C

货号:1369442
包装:25mg

美国药典标准品#1369442,环己亚硝尿相关化合物C,Lomustine Related Compound C (25 mg) (1,3-Dicyclohexylurea),CAS#2387-23-7

产品详情

货号:1369442
品名:Lomustine Related Compound C (25 mg) (1,3-Dicyclohexylurea)
中文名:环己亚硝尿相关化合物C
CAS #:2387-23-7
海关商品编码:2929909000
产地:US
来源:化学合成
规格:25mg
分类:药物标准品
商城价格:

Invent, Minute(TM) 血管总蛋白提取试剂盒, SA-03-BV


Minute(TM) 血管总蛋白提取试剂盒

货号:SA-03-BV
包装:Kit

  • 英文名:Minute(TM) Total Protein Extraction Kit for Blood Vessels
  • 级别:50tests
  • 品牌:Invent
  • Minute(TM) 血管总蛋白提取试剂盒,Minute(TM) Total Protein Extraction Kit for Blood Vessels, (货号:SA-03-BV),可以根据特定的下游应用选择变性细胞裂解缓冲液或天然细胞裂解缓冲液。

    产品详情质检信息

    价格:
    SA-03-BV / 3576.00(50tests)

    描述:血管组织(动脉和静脉)都是由特殊的结缔组织构成, 血管中有三层组织:膜、中膜和内皮。由于其独特的结构,血管组织非常难研磨匀浆,在提取总蛋白时也很难裂解。使用传统的溶液法提取蛋白质如RIPA,效率低,产率也很低,提取的蛋白质的图谱也是不完整的。本试剂盒利用离心管技术以及优化的裂解液,利用物理研磨和化学裂解相结合,提供了一种简单和快速的从人或动物血管组织中提取蛋白质的高效方法。可以根据特定的下游应用选择变性细胞裂解缓冲液或天然细胞裂解缓冲液。整个过程不到10分钟即可完成,蛋白质得率在1-3mg/ml。试剂盒所提供试剂及耗材可以满足客户50个样品实验。

    应用:SDS-PAGE, WB,IP,ELISA,酶活性测定和蛋白质组学分析。缓冲剂与IMAC树脂兼容,可用于His标签蛋白纯化。在质谱分析之前需将提取的蛋白质样品中的盐和表面活性剂除去。

    储存条件:常温

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    我公司全国总代理,华东地区代理omnimabs专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。

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    全国总代理,华东地区代理omnimabs产品涉及分子生物学、细胞生物学、细菌学、遗传学、免疫学、生物化学、蛋白质学、细胞疗、临床应用等领域。全国总代理,华东地区代理范围内免费运输,如出现运输质量问题,我们可以包退换货。omnimabs完善的库存及供应体系以及高效稳定的专利纯化技术,保证产品均能现货供应和产品质量的稳定性。
    品牌名称:   omnimabs
    【生物分子】 抗生素/抗真菌素 维生素 氨基酸 核苷酸 脂 糖类 白三烯 前列腺素 药物结合物 抗氧化剂 药理活性化合物 类固醇激素结合物 半抗原反应 半抗原载体结合物 放射性核素 血小板活化素 tRNA 活性染料和化合物 亲和素/链霉亲和素
    【蛋白质/抗原/多肽】 免疫球蛋白 封闭肽 人蛋白和抗原 小鼠蛋白和抗原 细菌蛋白和抗原 病毒蛋白和抗原 植物蛋白和抗原 其它蛋白和抗原 细胞质蛋白 总蛋白 膜蛋白 核蛋白 细胞裂解和提取物 线粒体蛋白 细胞裂解 组织提取 重组细胞因子
    【常用生化试剂】EDTA DTT Tris SDS MOPS HEPES 水 分子生物学缓冲液 蛋白生化缓冲液 去垢剂 染色试剂 溶剂 酸碱 化学试剂 其它生化试剂
    【PCR/RT-PCR/qPCR】PCR试剂 PCR对照 特异性PCR试剂盒 PCR克隆试剂盒 RNA 载体及构建 PCR克隆载体 M13克隆载体 细菌克隆载体 文库及构建 cDNA文库 基因组文库 噬菌体展示文库
    【酶】限制性内切酶 蛋白酶 核酸酶 激酶 聚合酶 连接酶
    【cDNA及合成纯化】cDNA全长基因 RNA cDNA合成 cDNA相关试剂
    【核酸/蛋白合成】Oligo纯化 核酸合成柱 核酸合成试剂
    【克隆与表达】克隆基因 克隆试剂盒 克隆筛选
    【表达分析】 Northern印迹分析 分支DNA和mRNA定量
    【蛋白分析】 PAGE凝胶制备 蛋白电泳试剂 预制蛋白凝胶
    【核酸纯化】 DNA凝胶纯化 DNA提取纯化 PCR产物纯化
    【RNAi技术】 siRNA 反义寡核苷酸 RNAi定量 RNAi文库
    【蛋白检测】 Western印迹 报告基因检测 蛋白检测试剂盒
    【实验动物】 转基因动物 小鼠 大鼠 模式动物
    【临床检测试剂】 生化检测 遗传学检测 血液检测
    【相关检验试剂】 食品安全检测 药品安全检测
    【蛋白纯化】 蛋白提取 蛋白透析 蛋白定量 蛋白稳定
    【细胞培养】 血清 血清替代物 细胞培养基 细胞 细胞株 感受态细胞 新鲜细胞分离
    【干细胞】 干细胞/祖细胞 原代细胞 干细胞培养基
    【蛋白修饰】 蛋白标记 载体蛋白结合 其它
    【细胞生物学检测】 细胞凋亡 细胞分离 细胞增殖
    【药物筛选】 荧光素细胞活力/增殖/毒性检测
    【免疫检测】 放射性免疫检测 化学发光免疫检测

    omnimabs抗体怎么样 omnimabs抗体 omnimabs官网omnimabs抗体怎么样 omnimabs抗体 omnimabs官网omnimabs www.omnimabs.com omni抗体

    固话总机:021-50837765
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    qq号:2743691513 1042640511
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    网 址: www.jinpanbio.com
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    橙皮甙标准品,Epihesperidin Standard,52026-3,中草药标准品|橙皮甙标准品|药物及代谢物|上海金畔生物科技有限公司


    橙皮甙标准品

    货号:085-08211
    包装:10mg

    Epihesperidin Standard CAS#:52026-3 品牌:wako;订货号:085-08211 类别:中草药标准品

    产品详情

     感谢您的关注,该商品暂无详细信息,请联系业务人员咨询 021-50837765,或咨询我们的在线客服。

    桩式试管架,填充聚丙烯,试管大小10-13,蓝色5977-0313LSP1CS

    桩式试管架,填充聚丙烯,试管大小10-13,蓝色桩式试管架,填充聚丙烯,试管大小10-13,蓝色桩式试管架,填充聚丙烯,试管大小10-13,蓝色桩式试管架,填充聚丙烯,试管大小10-13,蓝色5977-0313LSP1CS1CS

    上海金畔生物科技有限公司代理whatman全线产品

    固话总机:021-50837765
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    网 址: www.jinpanbio.com
    金畔博客:www.jinpanbio.cn

    Email:[email protected]

    Originally posted 2018-11-29 16:16:31.

    醚黄隆标准品,Cinosulfuron Standard,94593-91-6,wako农药标准品|醚黄隆标准品|农药标准品|上海金畔生物科技有限公司


    醚黄隆标准品

    货号:033-16441
    包装:200mg

    Cinosulfuron Standard CAS#:94593-91-6 品牌:wako;订货号:033-16441 类别:wako农药标准品

    产品详情

     感谢您的关注,该商品暂无详细信息,请联系业务人员咨询 021-50837765,或咨询我们的在线客服。

    美国药典标准品#1043331,积雪草苷,Asiaticoside (30 mg),CAS#16830-15-2


    积雪草苷

    货号:1043331
    包装:30mg

    美国药典标准品#1043331,积雪草苷,Asiaticoside (30 mg),CAS#16830-15-2

    产品详情

    货号:1043331
    品名:Asiaticoside (30 mg)
    中文名:积雪草苷
    CAS #:16830-15-2
    海关商品编码:2938900000
    产地:IT
    来源:植物
    规格:30mg
    分类:药物标准品/膳食补充剂标准品
    商城价格:

    Shibayagi 胰高血糖素样肽-1(GLP-1)(活性) ELISA试剂盒

    Shibayagi 胰高血糖素样肽-1(GLP-1)(活性) ELISA试剂盒
    Lbis GLP-1(active) ELISA KIT

    • 产品特性
    • 相关资料
    • Q&A
    • 参考文献

    Lbis GLP-1(active) ELISA KITShibayagi 胰高血糖素样肽-1(GLP-1)(活性) ELISA试剂盒

    Shibayagi 胰高血糖素样肽-1(GLP-1)(活性) ELISA试剂盒

    Shibayagi 胰高血糖素样肽-1(GLP-1)(活性) ELISA试剂盒

    胰高血糖素样肽-1(Glucagon-like peptide-1,GLP-1)是胰高血糖素前驱体的一部分。胰高血糖素前驱体于胰脏、小肠下部以及下丘脑中表达。该前驱体的构造中含有与糖代谢有关的各种各样的生理活性物质(胰高血糖素,肠高血糖素,胃泌酸调节素,GLP-1,GLP-2)的氨基酸序列。根据表达部位加工酶的特异性,胰脏主要分泌胰高血糖素,而小肠下部主要分泌肠高血糖素和胃泌酸调节素。GLP-1和GLP-2则存在于胰高血糖素前驱体后半的结构中。GLP-1由37个氨基酸组成,有2种生物活性形式,分别为GLP-1(7-37)和GLP-1 (7-36)酰胺。两者都存在于小肠下部、胰脏和下丘脑中,GLP-1(7-36)酰胺在下丘脑中占免疫反应GLP-1(IR-GLP-1)总量的55-94%,在小肠中占27-73%。但在胰脏中只有极少量存在。大部分哺乳类(如人类、大鼠、小鼠、牛、猪、狗等)的GLP-1结构相似。

     

    GLP-1: hdeferhaegtftsdvssylegqaakefiawlvkgrg  

    GLP 1(7-37): haegtftsdvssylegqaakefiawlvkgrg

    GLP 1(7-36) amide: haegtftsdvssylegqaakefiawlvkgr-NH2

     

    GLP-1与小肠上部分泌的GIP统称为肠促胰素。该类激素是葡萄糖浓度依赖性方式促进胰岛素分泌。同时具有抑制胃肠道蠕动和胃液分泌、抑制胰高血糖素的释放、促进生长抑素的分泌、使食欲减退,促进肠上皮细胞生长、以及外周组织促进非胰岛素依赖性的葡萄糖的消耗,并促进细胞的生长的作用。有报告指出该类激素与垂体激素的分泌也有关系。

    GLP-1(7-36)酰胺在生物体内代谢迅速,DPP-IV (dipeptidyl peptidase IV )会使其失去N-末端的两个氨基酸变为GLP-1(9-36)酰胺,GLP-1(7-37)变为GLP-1(9-37)后会失去活性。有报告指出,体外实验中,在犬的血浆中GLP-1(7-36)酰胺的半衰期是为61±9分,GLP-1(7-37)为132±16分。因此GLP-1的测定,取样的时候有必要使用DPP-IV抑制剂。

    此外,肠促胰素中的GIP则是最有力促进GLP-1分泌的激素。回肠中GLP-1的分泌不是食物直接刺激肠道而产生的,而是由于胆碱能和肽类的刺激所产生的。

    ◆特点

    ● 短时间测定(完全反应时间:5小时)

    ● 微量样品(标准操作用量:10 μl)可测

    ● 使用对环境无害的防腐剂

    ● 全部试剂均为液体,可直接使用

    ● 精密的测定精度和高再现性

    ◆构成

     

    组成

    状态

    容量

    (A) 抗体固相化 96 孔板

    洗净后使用

    96   wells(8×12)/1 块

    (B) GLP-1标准溶液(500 pg/mL

    稀释后使用

    200 μL/1 瓶

    (C) 缓冲液

    即用

    60 mL/1 瓶

    (D)生物素结合抗GLP-1抗体

    稀释后使用

    100 μL/1 瓶

    (E) 过氧化物・抗生物素蛋白结合物

    稀释后使用

    100 μL/1 瓶

    (F) 显色液(TMB)

    即用

    12 mL/1 瓶

    (H) 反应终止液(1M H2SO4)※小心轻放

    即用

    12 mL/1 瓶

    ( I ) 浓缩洗净液(10×)

    稀释后使用

    100 mL/1 瓶

    封板膜

    4 张

    使用说明书

    1 份

    ◆交叉反应

    ※交差率是1,000 pg/mL浓度时的数据

    动物类型

    对象物质

    反应性和反应率(%)

    Mouse/Rat

    GLP-1(7-36)amide

    100

    GLP-1(7-37)

    <   0.1

    GLP-1(1-37)

    GLP-1(9-36)amide

    GLP-2

    Glucagon(1-29)

    Insulin

    Secretin

    GIP

    VIP

    GRF

    Bovine

    Glucagon(1-29)

    VIP

    Porcine

    Glucagon(1-29)

    VIP

    ―:不存在交叉反应

    ◆样品信息

     

    小鼠和大鼠的血清及血浆

    10 μL/well(标准操作方法)

    ※测量中由于酶(DPP-IV等)的影响,采血时请注意防止GLP-1(7-36)酰胺的分解,再使用。

     

     

    ◆测定范围

     

    1.56~50.0 pg/mL 【0.47~15.16 pmol/L(分子量3298)】(标准曲线范围)

    7.8~250 pg/mL(样品量10 μ)

    3.9~125 pg/mL(样品量20 μ)

    ◆Validation data

     

    精度测试(检测内变异系数)

     

    样品

    A

    B

    1

    23.7

    6.44

    2

    23.2

    5.97

    3

    23.4

    6.39

    4

    24.0

    5.87

    5

    24.1

    6.44

    mean

    23.7

    6.22

    SD

    0.35

    0.28

    CV(%)

    1.5

    4.5

    单位:pg/mL

     

     

    再现性测试(检测内变异系数)

     

    测量日/样品

    E

    F

    第0天

    25.1

    6.31

    第1天

    25.1

    6.16

    第2天

    25.0

    6.24

    第3天

    25.0

    6.37

    mean

    25.0

    6.27

    SD

    0.03

    0.09

    CV(%)

    0.13

    1.4

    单位:pg/mL n=4

     

     

    添加回收测试

     

    样品C

    添加量

    实测值

    回收量

    回收率(%)

    0.00

    3.93

    3.26

    7.28

    3.35

    103

    6.51

    10.3

    6.37

    97.8

    8.14

    12.1

    8.17

    100

     

    样品D

    添加量

    实测值

    回收量

    回收率(%)

    0.00

    11.8

    7.16

    19.1

    7.30

    102

    14.3

    25.5

    13.7

    95.8

    21.5

    32.4

    20.6

    95.8

     

     

    稀释直线性测试

     

    用稀释缓冲液分三次连续稀释2个血清样品的结果,直线回归方程的R2在0.997~0.9999之间。

    相关资料


    Shibayagi 胰高血糖素样肽-1(GLP-1)(活性) ELISA试剂盒 Shibayagi 胰高血糖素样肽-1(GLP-1)(活性) ELISA试剂盒

    ELISA试剂盒选择指南①②

    ELISA试剂盒选择指③④

    参考文献

    1.

    Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease. Baumeier C, Schluter L, Saussenthaler S, Laeger T, Rodiger M, Alaze SA, Fritsche L, Haring HU, Stefan N, Fritsche A, Schwenk RW, Schurmann A. Mol Metab. 2017 Oct;6(10):1254-1263.


     2.

    Recombinant Mouse Osteocalcin Secreted by Lactococcus lactis Promotes Glucagon-Like Peptide-1 Induction in STC-1 Cells. Namai F, Shigemori S, Sudo K, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T. Curr Microbiol. 2017 Sep 13.


     3.

    A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation. Aoki R, Kamikado K, Suda W, Takii H, Mikami Y, Suganuma N, Hattori M, Koga Y. Sci Rep. 2017 Mar 2;7:43522.


     4.

    Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model. Kishida Y, Okubo H, Ohno H, Oki K, Yoneda M. J Gastroenterol. 2017 Mar 27.


     5.

    Fermented vegetable and fruit extract (OM-XŪ) stimulates murine gastrointestinal tract cells and RAW264. 7 cells in vitro and regulates liver gene expression in vivo. Wakame K, Nakata A, Sato K, Mihara Y, Takahata M, Miyake Y, Okada M, Shimomiya Y, and Komatsu K. Integr Mol Med, 2017 http://www.omx.co.jp/files/attachments/8e3f7824b69bece18acca14baf314b11.PDF

     6.

    Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice. Yang JY, Lee YS, Kim Y, Lee SH, Ryu S, Fukuda S, Hase K, Yang CS, Lim HS, Kim MS, Kim HM, Ahn SH, Kwon BE, Ko HJ, Kweon MN. Mucosal Immunol. 2017 Jan;10(1):104-116


     7.

    An extract from pork bones containing osteocalcin improves glucose metabolism in mice by oral administration. Mizokami A, Wang D, Tanaka M, Gao J, Takeuchi H, Matsui T, Hirata M. Biosci Biotechnol Biochem. 2016 Jul 27:1-8.


     8.

    Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice. Ushiama S, Ishimaru Y, Narukawa M, Yoshioka M, Kozuka C, Watanabe N, Tsunoda M, Osakabe N, Asakura T, Masuzaki H, Abe K. EBioMedicine. 2016 Jun;8:60-71.


     9.

    Dipeptidyl peptidase 4 inhibitor reduces intimal hyperplasia in rabbit autologous jugular vein graft under poor distal runoff. Koyama A, Komori K, Otsuka R, Kajikuri J, Itoh T. J Vasc Surg. 2016 May;63(5):1360-70.


    10.

    Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice. Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M. Vascul Pharmacol. 2016 Apr;79:16-23.


    11.

    Intestinal Bile Acid Composition Modulates Prohormone Convertase 1/3 (PC1/3) Expression and Consequent GLP-1 Production in Male Mice. Morimoto K, Watanabe M, Sugizaki T, Irie J, Itoh H. Endocrinology. 2016 Mar;157(3):1071-81.


    12.

    Total gastrectomy-induced reductions in food intake and weight are counteracted by rikkunshito by attenuating glucagon-like peptide-1 elevation in rats. Taguchi M, Dezaki K, Koizumi M, Kurashina K, Hosoya Y, Lefor AK, Sata N, Yada T. Surgery. 2016 Jan 13. pii: S0039-6060(15)01029-6


    13.

    DPP-4 inhibition has beneficial effects on the heart after myocardial infarction. Akihiko Kubota, Hiroyuki Takano, Haixiu Wang, Hiroshi Hasegawa, Hiroyuki Tadokoro, Masanori Hirose, Yuka Kobaraa, Tomoko Yamada-Inagawa, Issei Komuro, Yoshio Kobayashi. Journal of Molecular and Cellular Cardiology, Volume 91, Feb. 2016, Pages 72–80


    14.

    The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: Effects on peripheral sensory nerve function, structure and molecular changes. Tsuboi K, Mizukami H, Inaba W, Baba M, Yagihashi S. J Neurochem. Volume 136, Issue 4, pages 859–870, Feb. 2016


    15.

    Intestinal Bile Acid Composition Modulates Prohormone Convertase 1/3 (PC1/3) Expression and Consequent GLP-1 Production in male mice. Morimoto K, Watanabe M, Sugizaki T, Irie JI, Itoh H. Endocrinology. 2016 Jan 20:en20151551.


    16.

    Hypoxia decreases glucagon-like peptide-1 secretion from the GLUTag cell line. Kihira Y, Burentogtokh A, Itoh M, Izawa-Ishizawa Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tamaki T. Biol Pharm Bull. Vol.38(4), p514-21, 2015.


    17.

    Dietary obacunone supplementation stimulates muscle hypertrophy, and suppresses hyperglycemia and obesity through the TGR5 and PPARγ pathway. Horiba T, Katsukawa M, Mita M, Sato R. Biochem Biophys Res Commun. Vol.463(4), p846-52, Aug 2015.


    18.

    Combination of DPP-4 inhibitor and PPARγ agonist exerts protective effects on pancreatic β-cells in diabetic db/db mice through the augmentation of IRS-2 expression. Hirukawa H, Kaneto H, Shimoda M, Kimura T, Okauchi S, Obata A, Kohara K, Hamamoto S, Tawaramoto K, Hashiramoto M, Kaku K. Mol Cell Endocrinol. Jun 2015.


    19.

    Glucagon-like peptide-1 is specifically involved in sweet taste transmission. Takai S, Yasumatsu K, Inoue M, Iwata S, Yoshida R, Shigemura N, Yanagawa Y, Drucker DJ, Margolskee RF, Ninomiya Y. FASEB J. Vol.29(6), p2268-80, Jun 2015.


    20.

    Dipeptidyl-peptidase-4 inhibitor, alogliptin, attenuates arterial inflammation and neointimal formation after injury in low-density lipoprotein (LDL) receptor-deficient mice. Akita K, Isoda K, Shimada K, Daida H. J Am Heart Assoc. Vol.13;4(3):e001469, Mar 2015.


    21.

    Effects of sleeve gastrectomy and gastric banding on the hypothalamic feeding center in an obese rat model. Kawasaki T1, Ohta M, Kawano Y, Masuda T, Gotoh K, Inomata M, Kitano S.  Surg Today. 2015 Feb 28.


    22.

    Duodenal-jejunal bypass improves diabetes and liver steatosis via enhanced glucagon-like peptide-1 elicited by bile acids. Kashihara H, Shimada M, Kurita N, Sato H, Yoshikawa K, Higashijima J, Chikakiyo M, Nishi M, Takasu C. J Gastroenterol Hepatol. Vol.30(2), p308-15, Feb 2015.


    23.

    Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model. Okubo H, Nakatsu Y, Sakoda H, Kushiyama A, Fujishiro M, Fukushima T1, Matsunaga Y, Ohno H, Yoneda M, Kamata H, Shinjo T, Iwashita M, Nishimura F, Asano T. Am J Physiol Gastrointest Liver Physiol. Vol.15;308(2), G151-8, Jan 2015.


    24.

    Glucagon-like peptide-1 production in the GLUTag cell line is impaired by free fatty acids via endoplasmic reticulum stress. Hayashi H, Yamada R, Das SS, Sato T, Takahashi A, Hiratsuka M, Hirasawa N. Metabolism. Vol.63(6), p800-11. Jun 2014.


    25.

    MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice. Ohyama T, Sato K, Yamazaki Y, Hashizume H, Horiguchi N, Kakizaki S, Mori M, Kusano M, Yamada M. World J Gastroenterol.Vol.20(43), p16227-35, Nov 2014.


    26.

    Oral administration of osteocalcin improves glucose utilization by stimulating glucagon-like peptide-1 secretion. Mizokami A, Yasutake Y, Higashi S, Kawakubo-Yasukochi T, Chishaki S, Takahashi I, Takeuchi H, Hirata M. Bone. 16;69C:68-79. Sep 2014.


    27.

    Dietary sweet potato (Ipomoea batatas L.) leaf extract attenuates hyperglycaemia by enhancing the secretion of glucagon-like peptide-1 (GLP-1) . Nagamine R, Ueno S, Tsubata M, Yamaguchi K, Takagaki K, Hira T, Hara H, Tsuda T. Food Funct, Vol.5(9), p2309-2316, Aug 2014.


    28.

    Duodenal-jejunal bypass improves diabetes and liver steatosis via enhanced glucagon-like peptide-1 elicited by bile acids. Kashihara H, Shimada M, Kurita N, Sato H, Yoshikawa K, Higashijima J, Chikakiyo M, Nishi M, Takasu C. Journal of Gastroenterology and Hepatology, Aug 2014.


    29.

    Deletion of Hypoxia-Inducible Factor-1α in Adipocytes Enhances Glucagon-Like Peptide-1 Secretion and Reduces Adipose Tissue Inflammation. Kihira Y, Miyake M, Hirata M, Hoshina Y, Kato K, Shirakawa H, Sakaue H, Yamano N, Izawa-Ishizawa Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tamaki T, Tomita S. PLoS One. 2014 Apr 4;9(4):e93856


    30.

    Glucagon-like peptide-1 production in the GLUTag cell line is impaired by free fatty acids via endoplasmic reticulum stress. Hayashi H., Yamada R., Shankar Das S., Sato T., Takahashi A., Hiratsuka M., Hirasawa N. Metabolism – Clinical and Experimental, 2014.


    31.

    Dipeptidyl peptidase-4 inhibitor ameliorates early renal injury through its anti-inflammatory action in a rat model of type 1 diabetes. Kodera AR, Shikata K., Takatsuka T., Oda K., Miyamoto S., Kajitani N., Hirota D., Ono T., Usui HK., Makino H. Biochemical and Biophysical Research Communications, Vol.443(3), p828-833, Jan 2014.


    32.

    Novel insight into the distribution of L-cells in the rat intestinal tract. Hansen CF., Vrang N., Sangild PT., Jelsing J. Am J Transl Res, Vol.5(3), p347-358, 2013.


    33.

    Cinnamtannin A2, a Tetrameric Procyanidin, Increases GLP-1 and Insulin Secretion in Mice. Yamashita Y, Okabe M, Natsume M, Ashida H. Bioscience, Biotechnology, and Biochemistry , Vol.77(4), 2013


    34.

    The protective roles of GLP-1R signaling in diabetic nephropathy:possible mechanism and therapeutic potential. H.Fujita, T.Morii, H.Fujishima, T.Sato, T.Shimizu, M.Hosoba, K.Tsukiyama, T.Narita, T.Takahashi, D.J.Drucker, Y.Seino, and Y.Yamada. Kidney International, 2013


    35.

    Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlled db/db mice. K.Ishibashi., A.Hara., Y.Fujitani., T.Uchida., K.Komiya., M.Tamaki., H.Abe., T.Ogihara., A.Kanazawa., R.Kawamori and H.Watada. Biochem Biophys Res Commun, Vol.440(4), p570-575, Nov 2013.


    36.

    Vildagliptin preserves the mass and function of pancreatic β cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes. Hamamoto S, Kanda Y, Shimoda M, Tatsumi F, Kohara K, Tawaramoto K, Hashiramoto M and Kaku K. Diabetes, Obesity and Metabolism,Vol.15(2), p153-163, Feb 2013.


    37.

    Osteocalcin Induces Release of Glucagon-Like Peptide-1 and Thereby Stimulates Insulin Secretion in Mice. Mizokami A, Yasutake Y, Gao J, Matsuda M, Takahashi I, Takeuchi H and Hirata M. PLoS ONE 8(2): e57375. Feb 2013


    38.

    DPP4 inhibitor vildagliptin preserves β-cell mass through amelioration of endoplasmic reticulum stress in C/EBPB transgenic mice. Shinobu Shimizu, Tetsuya Hosooka, Tomokazu Matsuda, Shun-ichiro Asahara, Maki Koyanagi-Kimura, Ayumi Kanno, Alberto Bartolome, Hiroaki Etoh, Megumi Fuchita, Kyoko Teruyama, Hiroaki Takahashi, Hiroyuki Inoue, Yusuke Mieda, Naoko Hashimoto, Susumu Seino, and Yoshiaki Kido. J Mol Endocrinol, Vol.49, p125-135, Oct 2012.


    39.

    Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats. Inaba W, Mizukami H, Kamata K, Takahashi K, Tsuboi K and Yagihashi S. European Journal of Pharmacology,Vol.691(1-3), p297-306, Sep 2012.


    40.

    The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice. Jacob Jelsing, Niels Vrang, Soren B van Witteloostuijn, Michael Mark and Thomas Klein. J Endocrinol, Vol.214, p381-387, Sep 2012.


    41.

    Neural and humoral changes associated with the adjustable gastric band: insights from a rodent model. J Kampe, A Stefanidis, S H Lockie, W A Brown, J B Dixon, A Odoi, S J Spencer, J Raven and B J Oldfield. International Journal of Obesity, 27 Mar 2012.


    42.

    Neural and humoral changes associated with the adjustable gastric band: insights from a rodent model. J Kampe, A Stefanidis, S H Lockie, W A Brown, J B Dixon, A Odoi, S J Spencer, J Raven and B J Oldfield. International Journal of Obesity, 27 Mar 2012.


    43.

    Mate Tea(Ilex paraguariensis)Promotes Satiety and Body Weight Lowering in Mice:Involvement of Glucagon-Like Peptide-1. G, M, E, Hussein., H, Matsuda., S, Nakamura., M, Hamao., T, Akiyama., K, Tamura., and M, Yoshikawa. Biol.Pharm.Bull. Vol.34(12), p1849-1855, 2011.


    44.

    5-Hydroxy-eicosapentaenoic acid is an endogenous GPR119 agonist and enhances glucose-dependent insulin secretion. R, Kogure., K, Toyama., S, Hiyamuta., I, Kojima., S, Takeda.  Biochemical and Biophysical Research Communications Vol.416(1-2), p58-63, 2011.


    45.

    GLP-1 Secretion in Response to Oral and Luminal Palatinose (Isomaltulose) in Rats. T,Hira.,M,Muramatsu.,M,Okuno.and H,Hara. J Nutr Sci Vitaminol, Vol.57, p30-35, 2011.


    46.

    Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance. C,Arai.,N,Arai.,A,Mizote.,K,Kohno.,K,Iwaki.,T,Hanaya.,S,Arai.,S,Ushio.,S,Fukuda. Nutrition Research, Vol.30(12), p840-848, 2010.


    47.

    Imaging exocytosis of single glucagon-like peptide-1 containing granules in a murine enteroendocrine cell line with total internal reflection fluorescent microscopy. Ohara-Imaizumi,M.,Aoyagi,K.,Akimoto,Y.,Nakamichi,Y.,Nishiwaki,C.,Kawakami,H.and Nagamatsu,S. Biochemical and Biophysical Reseach Communications, Vol.390, p16-20, 2009.


    产品编号 产品名称 产品规格 产品等级 产品价格
    637-15129 (AKMGP-011) Lbis® GLP-1(Active) ELISA Kit
    Lbis® 胰高血糖素样肽-1(GLP-1)(活性) ELISA试剂盒 
    96 tests