AMG-1694CAS号: 1361217-07-3分子式: C23H30F3N3O4S2分子量: 533.63描述纯度储存/保存方法靶点In vitro(体外研究)
产品描述 | |
描述 |
AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation.
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纯度 |
98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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生物活性 | |
靶点 |
GK:0.02 μM(EC50), GK-GKRP:7 nM
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In vitro(体外研究) |
AMG-1694 demonstrates high efficacy in reinstating the enzymatic activity of GK in the presence of GKRP with an EC50 of 0.020 μM.[1]
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