PF-9363CAS号： 2569009-58-9分子式： C20H20N4O6S分子量： 444.46描述纯度储存/保存方法可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:55 mg/ml (123.75 mM)
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| 生物活性 | |
| In vitro(体外研究) |
PF-9363 (0~1 μM; 1 day) down-regulates the expression of H3K23Ac biomarker in ZR75-1, T47D and MCF7 cells[1]. PF-9363 downregulates a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. The IC50 values of PF-9363 for ZR75-1 and T47D are 0.3 nM and 0.9 nM[1].
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| In vivo(体内研究) |
PF-9363 exihibits strong anti-tumor activity in patient-derived xenograft models[1].
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