SD-169CAS号: 1670-87-7分子式: C9H8N2O分子量: 160.2描述应用纯度储存/保存方法形态别名外观熔点折射率IC50可溶性/溶解性MDLPubChem CID靶点
产品描述 | |
描述 |
SD-169 is an ATP-competitive and orally bioactive inhibitor of p38α MAP kinase (IC50 = 3.2 nM) with 38 fold selectivity over p38β MAP kinase (IC50 = 122 nM). SD-169 decreases p38 MAP kinase expression in T cells, lowers blood glucose and reduces the risk of diabetes. It has no inhibitory effect against a panel of other kinases including p38γ MAP kinase, ERK2, JNK-1 and MAPKAPK-2. |
应用 |
A selective inhibitor of p38α and p38β
|
纯度 |
98%
|
储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
|
形态 |
Solid
|
基本信息 | |
别名 |
5-Carboxamidoindole
|
外观 |
Off-white solid
|
熔点 |
159-163° C
|
折射率 |
n20D 1.72
|
IC50 |
p38α MAP kinase: IC50 = 3.2 nM; p38β MAP kinase: IC50 = 122 nM; p38γ: IC50 = >50 µM
|
可溶性/溶解性 |
DMSO : 100 mg/mL (624.30 mM; Need ultrasonic)
|
MDL |
MFCD07779486
|
PubChem CID |
14973220
|
生物活性 | |
靶点 |
p38α MAPK,p38β MAPK
|
分子结构图