AG 126CAS号： 118409-62-4分子式： C10H5N3O3分子量： 215.17描述纯度储存/保存方法别名外观可溶性/溶解性靶点
| 产品描述 | |
| 描述 |
The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 μM) and platelet-derived GFRK (IC50 > 100 μM). |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
酪氨酸磷酸化抑制剂126；Tyrphostin AG 126；AG-126
|
| 外观 |
Yellow solid
|
| 可溶性/溶解性 |
DMSO : 100 mg/mL (464.75 mM; Need ultrasonic and warming)
|
| 生物活性 | |
| 靶点 |
COX-2,15.38µm,ERK1,2,(EC)25-50Μm,ERK1,ERK2
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分子结构图
