VU0650786CAS号： 1809085-30-0分子式： C18H15ClFN5O2分子量： 387.80描述纯度储存/保存方法别名可溶性/溶解性靶点In vivo(体内研究)
| 产品描述 | |
| 描述 |
VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
VU786
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| 可溶性/溶解性 |
DMSO : 250 mg/mL (644.66 mM; Need ultrasonic)
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| 生物活性 | |
| 靶点 |
mGluR3
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| In vivo(体内研究) |
VU0650786 (VU786) (i.p., 30 mg/kg) increases the proportion of c-Fos-positive cells by approximately 4-fold, enhances synaptic strength in cone cell subpopulations, weakens thalamocortical long-term depression (LTD), and reduces passive coping in acute models of antidepressant-like activity in inducible cFos-EGFP mice.
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分子结构图
