K 114CAS号: 872201-12-2分子式: C22H17BrO2分子量: 393.27描述应用纯度储存/保存方法形态别名外观折射率IC50PK值可溶性/溶解性MDLPubChem CID
产品描述 | |
描述 |
K 114 is a potent amyloid fibril-specific fluorescent dye similar to Congo Red and BSB . K 114 recognizes amyloid lesions and facilitates quantitative monitoring of the formation of amyloid fibrils assembled from the Aβ peptide, α-synuclein, and tau. The affinity for fibrils ranges 20-30 nM. Unlike the other compounds K114 has minimal fluorescence in aqueous buffers, but fluoresces brightly in the presence of amyloid fibrils. K114 can be used to monitor in vitro amyloid fibril formation by fluorescence emission at 550 nm.
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应用 |
A potent amyloid fibril-specific fluorescent dye
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纯度 |
≥98%
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储存/保存方法 |
Store at 4° C
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形态 |
Solid
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基本信息 | |
别名 |
(trans,trans)-1-Bromo-2,5-bis-(4-hydroxy)styrylbenzene; K114
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外观 |
white to beige powder
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折射率 |
n20D 1.78 (Predicted)
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IC50 |
amyloid fibril-specific fluorescent dye: EC5050 = 20 – 30 nM
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PK值 |
pKa: 9.92 (Predicted)
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可溶性/溶解性 |
Soluble in DMSO (100 mM ), and ethanol (50 mM ).
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MDL |
MFCD11045294
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PubChem CID |
44828481
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分子结构图