K 114 is a potent amyloid fibril-specific fluorescent dye similar to Congo Red and BSB . K 114 recognizes amyloid lesions and facilitates quantitative monitoring of the formation of amyloid fibrils assembled from the Aβ peptide, α-synuclein, and tau. The affinity for fibrils ranges 20-30 nM. Unlike the other compounds K114 has minimal fluorescence in aqueous buffers, but fluoresces brightly in the presence of amyloid fibrils. K114 can be used to monitor in vitro amyloid fibril formation by fluorescence emission at 550 nm.

A potent amyloid fibril-specific fluorescent dye

≥98%

Store at 4° C

Solid

(trans,trans)-1-Bromo-2,5-bis-(4-hydroxy)styrylbenzene; K114

white to beige powder

n²⁰_D 1.78 (Predicted)

amyloid fibril-specific fluorescent dye: EC₅₀50 = 20 – 30 nM

pK_a: 9.92 (Predicted)

Soluble in DMSO (100 mM ), and ethanol (50 mM ).

MFCD11045294

44828481