UA62784CAS号: 313367-92-9分子式: C23H15NO3分子量: 353.37描述应用纯度储存/保存方法形态别名外观可溶性/溶解性MDLPubChem CID
产品描述 | |
描述 |
UA62784 is a fluorenone specific inhibitor of CENP-E(centromere protein E), which is a kinesin-like motor protein. It is known that CENP-E migrates towards the kinetochore during mitosis and is essential in spindle formation. UA62784 acts as a specific inhibitor of CENP-E via binding to the motor domain of the protein. As a result of this inhibition cell cycle arrest occurs during metaphase via inhibiting chromosome congregation at the metaphase plate. It is believed that this is a result of UA62784’s ability to inhibit CENP-E microtubule associated ATPase activity. Furthermore, UA62784 can selectively destroy pancreatic cancer locus 4-deficient cancer cells.
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应用 |
A centromere protein E (CENP-E) inhibitor
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纯度 |
≥98%
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储存/保存方法 |
Store at 4° C
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形态 |
Solid
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基本信息 | |
别名 |
4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one
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外观 |
Powder
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可溶性/溶解性 |
Solubility: Soluble in DMSO and Water
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MDL |
MFCD00489199
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PubChem CID |
3383533
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