CYM 5520CAS号: 1449747-00-5分子式: C21H19N3O2分子量: 345.4描述纯度储存/保存方法参考文献
产品描述 | |
描述 |
Sphingosine-1-phosphate (S1P; Item No. 62570) is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P2 has been implicated in multiple biological functions, including Rho activation, inhibition of Rac and cell migration, and in “feed forward” autocrine signaling in NF-κB survival signaling of tumor cells.1 CYM 5520 is a noncompetitive allosteric agonist of S1P2 (EC50 = 0.48 μM) that does not display agonist activity towards S1P1, S1P3, S1P4, or S1P5.1
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纯度 |
≥95%
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储存/保存方法 |
Store at -20℃
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参考文献 | |
参考文献 |
1.Satsu, H.,Schaeffer, M.T.,Guerrero, M., et al. A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorganic & Medicinal Chemistry 21(17), 5373-5382 (2013).
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分子结构图