Sphingosine-1-phosphate (S1P; Item No. 62570) is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors, S1P₁/EDG-1, S1P₂/EDG-5, S1P₃/EDG-3, S1P₄/EDG-6, and S1P₅/EDG-8. S1P₂ has been implicated in multiple biological functions, including Rho activation, inhibition of Rac and cell migration, and in “feed forward” autocrine signaling in NF-κB survival signaling of tumor cells.¹ CYM 5520 is a noncompetitive allosteric agonist of S1P₂ (EC₅₀ = 0.48 μM) that does not display agonist activity towards S1P₁, S1P₃, S1P₄, or S1P₅.¹

≥95%

Store at -20℃

1.Satsu, H.,Schaeffer, M.T.,Guerrero, M., et al. A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorganic & Medicinal Chemistry 21(17), 5373-5382 (2013).