DKM 2-93CAS号： 65836-72-8分子式： C11H14ClNO3分子量： 243.69描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430 μM. |
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
2-氯-N-((3,4-二甲氧苯基)甲基)乙酰胺
|
| 可溶性/溶解性 |
DMSO ：49 mg/mL (201.08 mM)
Ethanol ：14 mg/mL (57.45 mM) |
| 生物活性 | |
| 靶点 |
UBA5,PaCa2 cells,Panc1 cells
|
| In vitro(体外研究) |
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC50s of 90 and 30 μM, respectively.
|
| In vivo(体内研究) |
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
|
分子结构图
