Pyridostatin(RR 82) trifluoroacetateCAS号： 1472611-44-1；1085412-37-8(free base)分子式： C31H32N8O5.xC2HF3O2分子量： 596.64(free base)描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
Pyridostatin stabilizes G-quadruplexes, targeting the proto-oncogene SRC and telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
RR82,RR-82,RR 82
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| 外观 |
Powder
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| 可溶性/溶解性 |
DMSO 100 mg/mL
Water 100 mg/mL Ethanol 30 mg/mL |
| 生物活性 | |
| 靶点 |
G-quadruplex
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| In vitro(体外研究) |
Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes.
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分子结构图
