Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD⁺ by NMN adenyltransferase. Cancer cells commonly have an unusually high rate of NAD⁺ turnover, suggesting that inhibition of Nampt might selectively target cancer cells. ​GPP 78 is a potent inhibitor of Nampt (IC₅₀ = 3 nM).¹ It induces cell death in the neuroblastoma cell line SH-SY5Y with an IC₅₀ value of 3.8 nM through a process that appears to involve autophagy.²

≥95%

Store at -20℃

CAY10618;NMPRTase Inhibitor;

1.Colombano, G.,Travelli, C.,Galli, U., et al. A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. Journal of Medicinal Chemistry 53, 616-623 (2010).

2.Stein, R.L.,Melandri, F. and Dick, L. Kinetic characterization of the chymotryptic activity of the 20S proteasome. Biochemistry 35, 3899-3908 (1996).