AC-73 is an orally available Cluster of Differentiation 147 (CD147) inhibitor with high bioavailability that selectively disrupts the dimerization of CD147 (the binding site is in the N-terminal IgC2 domain of CD147 including Glu64 and Glu73), resulting in inhibition of the CD147/ERK1/2/STAT3/MMP-2 pathway and inhibition of liver cancer cell motility and invasion. AC-73 has antiproliferative activity and induces autophagy in leukemia cells.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

DMSO:100 mg/mL (313.09 mM)

AC-73 (5-10 μM; 24 hours; SMMC-7721 and Huh-7 cells) treatment results in a dose-dependent reduction in the migration ability of SMMC-7721 and Huh-7 cells, as well as a dose-dependent decrease in the invasion of these two HCC cell lines at 24 hours. AC-73 treatment leads to a reduction in HCC metastasis. When treating the two HCC cell lines with AC-73 at a maximum concentration of 20 μM, there are no significant effects on cell viability. AC-73 potentially binds to CD147 at Glu64 and Glu73 in the N-terminal IgC2 domain, where both residues are situated within the dimer interface of CD147.[1]
AC-73 (5-10 μM; 24 hours; SMMC-7721 cells), at a concentration of 10 μM, significantly inhibits the mRNA expression of both MMP-2 and MMP-9, with a more pronounced effect on MMP-2, while demonstrating no discernible impact on MMP-1, MMP-3, MMP-7, MMP-11, or MMP-13. AC-73 exhibits a dose-dependent reduction in MMP-2 mRNA levels and protein secretion, as confirmed through RT-qPCR analysis and gelatin zymography experiments.[1]
AC-73 (5-20 μM; 6 hours; SMMC-7721 cells), in a dose-dependent manner, attenuates the phosphorylation of ERK1/2 and STAT3.[1]

AC-73 (25-50 mg/kg; Injected; daily; for 3 weeks; Male BALB/c nu/nu mice with SMMC-7721 cells) treatment significantly decreases the incidence of metastatic foci in nude mice. AC-73 inhibits the phosphorylation of ERK1/2 and STAT3 in a dose-dependent manner. MMP-2 is also reduced by AC-73. AC-73 could not inhibit tumor cell proliferation in vivo.[1]