Mouse Monoclonal Antibody (Mab)

ANPEP抗体, CD13抗体;Aminopeptidase N; AP-N; hAPN; Alanyl aminopeptidase; Aminopeptidase M; AP-M; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; gp150; CD13; ANPEP; APN; PEPN

Mouse

Purified His-tagged ANPEP protein(Fragment) was used to produced this monoclonal antibody.

Human

WB~~1:100~500

Predicted molecular weight: 110kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Monoclonal Antibody

496CT9.1.1

IgG1

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Cardiovascular;Cell Biology;Immunology;Signal Transduction

Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.

Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol. Note=A soluble form has also been detected

P15144

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Curnis, F., et al. J. Biol. Chem. 285(12):9114-9123(2010)
Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :
Ito, S., et al. Gen Thorac Cardiovasc Surg 57(11):591-598(2009)
Ju, S., et al. Cell Cycle 8(16):2578-2585(2009)