GNE-495CAS号： 1449277-10-4分子式： C22H20FN5O2分子量： 405.42描述纯度储存/保存方法可溶性/溶解性靶点In vivo(体内研究)参考文献
| 产品描述 | |
| 描述 |
GNE-495 是一种有效的选择性 MAP4K4 抑制剂，IC50 为 3.7 nM。 |
| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO: 10 mg/mL
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| 生物活性 | |
| 靶点 |
MAP4K
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| In vivo(体内研究) |
GNE-495 is administered intraperitoneally to neonatal mouse pups at high doses: 25 and 50 mg/kg. GNE-495 shows good in vivo profile in all species tested, with low clearances, moderate terminal half-lives, and reasonable oral exposure levels (F=37-47%).
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| 参考文献 | |
| 参考文献 |
[1]. Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med Chem Lett. 2015 Jun 29;6(8):913-8.
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分子结构图
