GNE-493CAS号： 1033735-94-2分子式： C17H20N6O2S分子量： 372.44描述纯度储存/保存方法可溶性/溶解性参考文献
| 产品描述 | |
| 描述 |
GNE-493 is a potent, selective and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitor for the treatment of cancer. The PI3K/AKT/mTOR pathway has been shown to play an important role in cancer. GNE-493 is highly selective, demonstrate knock down of pathway markers in vivo, and is efficacious in xenograft models where the PI3K pathway is deregulated. |
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 可溶性/溶解性 |
DMSO : ≥ 45 mg/mL
|
| 参考文献 | |
| 参考文献 |
Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. Sutherlin DP,et al. J Med Chem. 2010 Feb 11;53(3):1086-97. PMID: |
分子结构图
