AG 490, m-CF3CAS号： 581797-29-7分子式： C18H13F3N2O3分子量： 362.3描述应用别名密度熔点沸点折射率IC50可溶性/溶解性SMILES储存/保存方法PubChem CID
| 产品描述 | |
| 描述 |
AG 490, m-CF3 is a cell-permeable, m-trifluoromethyl derivative of AG 490 that displays apoptotic and antiproliferative properties. AG 490, m-CF3 inhibits IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly decreases lymph node cellularity in a murine model for B and T cell lymphoma.
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| 应用 |
An apoptotic and antiproliferative compound
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| 基本信息 | |
| 别名 |
α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide; NSC D722757
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| 密度 |
~1.4 g/cm3 (Predicted)
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| 熔点 |
233.60° C (Predicted)
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| 沸点 |
~593.7° C at 760 mmHg (Predicted)
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| 折射率 |
n20D 1.61 (Predicted)
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| IC50 |
2E8: IC50 = 1.7 µM; Baf/3 : IC50 = 2.8 µM; Jurkat cells: IC50 = 6.1 µM
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| 可溶性/溶解性 |
Soluble in DMSO (0.5 mg/ml), and methanol.
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| SMILES |
C1=CC(=CC(=C1)C(F)(F)F)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
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| 储存/保存方法 |
Store at -20° C
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| PubChem CID |
11516050
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