ZY-19489 is an antimalarial compound that is a potential single-dose cure for Plasmodium falciparum and Plasmodium vivax malaria. It has received orphan drug designation from the FDA.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

DMSO:4.66 mg/mL (10 mM)

Pf:9 nM, hERG:33 μM, α1A:1.2 μM, M2:2 μM

ZY-19489 showed the best potency (9 nM) combined with a >1,000-fold selectivity against hERG and AChE compared.[1]

12 displayed improved bioavailability (80%) as compared with its demethylated analog, 9 owing to its improved Caco2 permeability.[1]