CepharanthineCAS号: 481-49-2分子式: C37H38N2O6分子量: 606.71描述纯度储存/保存方法别名外观可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
产品描述 | |
描述 |
Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production. |
纯度 |
>98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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基本信息 | |
别名 |
千金藤素;千金藤碱
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外观 |
White or light yellow powder
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可溶性/溶解性 |
DMSO : 50 mg/mL (82.41 mM; Need ultrasonic)
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生物活性 | |
In vitro(体外研究) |
Treatment of SaOS2 cells with Cepharanthine (CEP) (2.5-20 μmol/L) inhibits the cell growth in a concentration- and time-dependent manner. CEP (10 μmol/L) caused cell cycle arrest at G(1) phase and induced apoptosis of SaOS2 cells. CEP (10 and 15 μmol/L) significantly decreases the expression of STAT3 in SaOS2 cells. Furthermore, CEP (5 and 10 μmol/L) significantly inhibits the expression of target genes of STAT3, including the anti-apoptotic gene Bcl-xL and the cell cycle regulators c-Myc and cyclin D1.
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In vivo(体内研究) |
In nude mouse xenografts of SaOS2 cells, Cepharanthine (CEP) (20 mg•kg(-1)•d(-1), ip for 19 d) significantly reduces the volume and weight of the tumor.
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分子结构图