菲律平CAS号： 480-49-9分子式： C35H58O11分子量： 654.83描述外观纯度应用别名可溶性/溶解性储存/保存方法参考文献
| 产品描述 | |
| 描述 |
Filipin III is a pentaene macrolide antibiotic and the predominant isomer of four isomeric polyene macrolides isolated from cultures of S. filipinensis. Due to Filipin III’s ability to fluoresce and bind to cholesterol, the compound has been used to detect cholesterol in membranes through freeze fracture electron microscopy and through decreased fluorescence of Filipin III upon binding. The compound has also been used in tobacco cells and observed to activate ligand-independent signaling responses. Through Filipin III’s cholesterol sequestering activity, the compound was able to disrupt the lipid rafts in both normal and transformed keratinocytes resulting in inhibition of the AKT pathway. |
| 外观 |
A crystalline solid
|
| 纯度 |
>90%
|
| 应用 |
A cholesterol-binding, fluorescing antibiotic
|
| 基本信息 | |
| 别名 |
菲律宾菌素；菲律平III; filimarisin
|
| 可溶性/溶解性 |
DMSO: 10 mg/ml
|
| 储存/保存方法 |
Store at -20° C，2 years.
|
| 参考文献 | |
| 参考文献 |
1. Severs, N.J., et al. 1983. Biochim. Biophys. Acta. 737: 373-408. PMID: 6349687
2. Miller, R.G. 1984. Cell Biol. Int. Rep. 8: 519-535. PMID: 6378397 3. Castanho, M.A., et al. 1992. J. Biol. Chem. 267: 204-209. PMID: 1730589 4. Bonneau, L., et al. 2010. Biochim. Biophys. Acta. 1798: 2150-2159. PMID: 20674542 5. Calay, D., et al. 2010. J. Invest. Dermatol. 130: 1136-1145. PMID: 20054340 |
分子结构图
