ARL 17477 dihydrochlorideCAS号： 180983-17-9分子式： C20H20ClN3S•2HCl分子量： 442.83描述应用储存/保存方法形态别名IC50可溶性/溶解性PubChem CID
| 产品描述 | |
| 描述 |
ARL 17477 dihydrochloride is a selective NOS1 (nNOS) inhibitor with IC50 values of 1 and 17 μM for NOS1 and NOS3, respectively. This compound has been shown to reduce ischemic cell damage after middle cerebral artery (MCA) occlusion in rats. Furthermore, ARL 17477 dihydrochloride has been shown to display a synergistic neuroprotective effect when combined with either an NMDA or AMPA receptor antagonist.
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| 应用 |
A selective NOS1 inhibitor
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| 储存/保存方法 |
Desiccate at room temperature
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| 形态 |
Solid
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| 基本信息 | |
| 别名 |
N’-[4-[2-[(3-chlorophenyl)methylamino]ethyl]phenyl]thiophene-2-carboximidamide;dihydrochloride
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| IC50 |
NOS1: IC50 = 1 µM; NOS3: IC50 = 17 µM
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| 可溶性/溶解性 |
Soluble in water (50 mM), and DMSO (100 mM).
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| PubChem CID |
9824646
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