PF-04753299CAS号: 1289620-49-0分子式: C18H21NO4S分子量: 347.43描述纯度储存/保存方法可溶性/溶解性In vivo(体内研究)
产品描述 | |
描述 |
PF-04753299 is a potent and selective inhibitor of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC). PF-04753299 is bactericidal for the gonococcal isolates. PF-04753299 inhibits E. coli, P. aeruginosa and K. pneumoniae strains with MIC 90 values of 2 μg/ml, 4 μg/ml and 16 μg/ml, respectively. PF-04753299 is used for the study of gram-negative bacteria infection [1].
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纯度 |
98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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基本信息 | |
可溶性/溶解性 |
DMSO:18mg/mL (51.8mM)
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生物活性 | |
In vivo(体内研究) |
Mice were administered PF-04753299 (subcutaneous dose; vehicle: 40% β cyclodextrin in water) 0.5 and 4 h after an intraperitoneal challenge of Pseudomonas aeruginosa strain UC12120, a penicillin-resistant, quinolone-sensitive clinical isolate (1a MIC = 0.25 μg/mL). At 24 h postinfection, the animals were sacrificed and the bacterial burden in the spleen was determined. The drug dose providing 50% bacterial burden reduction relative to untreated animals (ED50) was determined to be 35 mg/kg[2].
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