LY-2584702 free base CAS号： 1082949-67-4分子式： C21H19F4N7分子量： 445.42描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
LY-2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1. |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
LY2584702
|
| 外观 |
Yellow powder
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| 可溶性/溶解性 |
DMSO : ≥ 4.5 mg/mL (10.10 mM)
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| 生物活性 | |
| 靶点 |
p70S6K
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| In vitro(体外研究) |
In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus.
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| In vivo(体内研究) |
LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models.
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分子结构图
