PF-06446846CAS号： 1632250-49-7分子式： C22H20ClN7O分子量： 433.9描述纯度储存/保存方法可溶性/溶解性In vivo(体内研究)
| 产品描述 | |
| 描述 |
PF 06446846 is a potent and selective PCSK9 inhibitor
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:4.34 mg/mL (10 mM)
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| 生物活性 | |
| In vivo(体内研究) |
PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?PF-06446846 is highly selective for the inhibition of PCSK9 translation.?The mechanism of action employed by PF-06446846 reveals a previously unexpected tunability of the human ribosome that allows small molecules to specifically block translation of individual transcripts.
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