AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

cAMP:17 nM (EC50s), cGMP:50 nM (EC50s)

AZD5462 (example 1) exhibits stimulatory activity on cAMP or cGMP production with EC50s of 17 nM and 50 nM, respectively[1].
Binding to human plasma proteins with a fraction unbound (free) rate of 4.3%, AZD5462 demonstrates stability with Clint values of 23 μL/min/mg (human liver microsomal), 4.8 μL/min/10^6 cells (human hepatocyte), and 11 μL/min/10^6 cells (rat hepatocyte)[1].
AZD5462 enhances the phosphorylation of ERK with an EC50 value of 6.3 nM[1].