O-7460CAS号: 1572051-31-0分子式: C25H48FO5P分子量: 478.6描述纯度储存/保存方法参考文献
产品描述 | |
描述 |
In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG; Item No. 62160) by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM).1 It demonstrates much weaker inhibition towards human monoacylglycerol lipase and rat brain fatty acid amide hydrolase (IC50s > 10 µM) and does not bind to CB1 or CB2 cannabinoid receptors (Kis > 10 µM).1 At 0-12 mg/kg, i.p. in mice, O-7460 was reported to dose-dependently inhibit high-fat diet intake and reduce body weight.1
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纯度 |
≥95%
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储存/保存方法 |
Store at -20℃
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参考文献 | |
参考文献 |
1.Bisogno, T.,Mahadevan, A.,Coccurello, R., et al. A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects. British Journal of Pharmacology (2012).
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分子结构图