CE-245677CAS号： 717899-97-3分子式： C24H22Cl2N6O3分子量： 513.38描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:125 mg/mL (243.48 mM)
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| 生物活性 | |
| 靶点 |
Tie-2:4.7 nM, TrkB:1 nM, TrkA:1 nM
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| In vitro(体外研究) |
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM. Which displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1].
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| In vivo(体内研究) |
In vivo rat, CE-245677 displays good oral JPorption PK studies (F=80%)[1].
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