CGP 74514ACAS号： 481724-82-7分子式： C19H24ClN7分子量： 385.89描述应用纯度储存/保存方法形态别名外观IC50可溶性/溶解性PubChem CID
| 产品描述 | |
| 描述 |
CGP 74514A is a cell permeable, potent, and selective inhibitor of CDK1/cyclin B (IC50 = 25 nM). CGP 74514A is reported to affect the activities of other kinases only at much higher concentrations, such as PKCα (IC50 = 6.1 μM), PKA (IC50 = 125 μM) and EGFR (IC50 > 10 μM). CGP 74514A induces mitochondrial damage and apoptosis in several human leukemia cell lines (>3μM).
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| 应用 |
An inhibitor of CDK1/cyclin B, PKCα, PKA, and EGFR
|
| 纯度 |
≥95%
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| 储存/保存方法 |
Store at -20° C
|
| 形态 |
Solid
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| 基本信息 | |
| 别名 |
2-N-(2-aminocyclohexyl)-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine; AC1NELAR
|
| 外观 |
White to yellow solid
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| IC50 |
Cdk1/cyclin B: IC50 = 25 nM; PKCα: IC50 = 6.1 µM; EGFR: IC50 = >10 µM; PKA: IC50 = 125 µM
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| 可溶性/溶解性 |
Soluble in DMSO (10 mg/ml).
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| PubChem CID |
2794188
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分子结构图
