CRA-026440 HydrochlorideCAS号: 847459-98-7分子式: C23H25ClN4O4分子量: 456.92描述纯度储存/保存方法可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
产品描述 | |
描述 |
CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor. CRA-026440 hydrochloride exhibits Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM, respectively. CRA-026440 hydrochloride exhibits antitumor and antiangiogenic activities.
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纯度 |
98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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基本信息 | |
可溶性/溶解性 |
DMSO : 50 mg/mL (109.43 mM)
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生物活性 | |
In vitro(体外研究) |
CRA-026440 hydrochloride exhibits anti-proliferation effect on HUVEC endothelial cells with GI50 of 1.41 μM. CRA-026440 hydrochloride leads to the accumulation of acetylated histone and acetylated tubulin, thus inhibiting the growth of tumor cells and inducing cell apoptosis. CRA-026440 hydrochloride inhibits angiogenesis in vitro in a dose-dependent manner[1].
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In vivo(体内研究) |
CRA-026440 hydrochloride (100 mg/kg; intravenous injection; daily; three consecutive days) resulted in a significant decrease in tumor growth in mice carrying HCT116 or U937 human tumor xenografts[1].
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分子结构图