Trifluoperazine dihydrochlorideCAS号： 440-17-5分子式： C21H24F3N3S.2HCl分子量： 480.42描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
盐酸三氟拉嗪；三氟拉嗪二盐酸盐; TFP；SKF5019
|
| 外观 |
white to off-white powder
|
| 可溶性/溶解性 |
Ethanol ：89 mg/mL (185.3 mM)
DMSO ：82 mg/mL (170.7 mM) Water ：88 mg/mL (183.2 mM) |
| 生物活性 | |
| 靶点 |
Dopamine D2 receptor
|
| In vitro(体外研究) |
Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. Trifluoperazine ( Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1).
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| In vivo(体内研究) |
Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance.
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分子结构图
