CUDC-427CAS号： 1446182-94-0分子式： C29H36N6O4S分子量： 564.7描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers.
|
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
GDC-0917
|
| 可溶性/溶解性 |
DMSO : 50 mg/mL (88.54 mM; Need ultrasonic)
|
| 生物活性 | |
| 靶点 |
IAP
|
| In vitro(体外研究) |
GDC-0917 (0.1 nM-10 μM) induces reduction of cIAP1 levels in PBMCs in a concentration-dependent manner showing greater than 80% inhibition at concentrations greater than 0.1 µM (56.5 ng/mL).
|
| In vivo(体内研究) |
GDC-0917 (0.08-16.3 mg/kg) exhibits antitumor activity in a dose dependent manner in the MDA-MB-231-X1.1 Breast Cancer Xenograft, and GDC-0917 is well tolerated, with all dose groups experiencing a .
|
分子结构图
