BYK204165CAS号： 1104546-89-5分子式： C15H12N2O2分子量： 252.27描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
BYK204165 is a potent and selective PARP1 inhibitor. BYK204165 inhibits cell-free recombinant human PARP-1 (hPARP-1) with a pIC50 of 7.35 (pKi=7.05), and murine PARP-2 (mPARP-2) with a pIC50 of 5.38, respectively. BYK204165 displays 100-fold selectivity for PARP-1.
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| 纯度 |
≥98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
PARP Inhibitor XIV; BYK 204165
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| 外观 |
yellow Powder
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| 可溶性/溶解性 |
DMSO : 125 mg/mL (495.50 mM; Need ultrasonic)
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| 生物活性 | |
| 靶点 |
hPARP-1；mPARP-2
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| In vitro(体外研究) |
In kinetic experiments with human PARP-1, BYK204165 exhibits potent and competitive inhibition of enzyme activity, yielding a pKi value of 7.05[1]. BYK204165 exhibits low potency of PARP inhibition in C4I cells (pIC50 of 5.75).
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| In vivo(体内研究) |
BYK204165 is not investigated in vivo because of its short half-time (t1/2) of 23 min measured at rat microsomes in vitro.
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分子结构图
