JAK3 Inhibitor VII, AD412CAS号: 796041-65-1分子式: C23H20ClN3O分子量: 389.88描述应用储存/保存方法别名PubChem CID
产品描述 | |
描述 |
JAK3 Inhibitor VII, AD412 is a cell-permeable indole-3-propanamide immunosuppressant that is shown to selectively inhibit JAK3 kinase activity (by 81% and 36% at 90 and 30 μM, respectively) over that of JAK2 (by 29% and 0% at 90 and 30 μM, respectively) and reduce JAK1 and JAK3-dependent phosphorylations of Akt, STAT5a/b, and Erk1/2 in IL-2-stimulated CTL-L2 cells, but not JAK1/2-dependent STAT1 phosphorylation in INF-γ-stimulated U266 cultures. JAK3 Inhibitor VII, AD412 is reported to inhibit ConA-stimulated murine splenocytes and PHA-stimulated human PBL proliferation (IC50 = 17 and 25 μM, respectively) in vitro.
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应用 |
A selective inhibitor of JAK3
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储存/保存方法 |
Store at 4° C
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基本信息 | |
别名 |
N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
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PubChem CID |
16723801
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