Plx-4032CAS号： 1029872-54-5分子式： C23H18ClF2N3O3S分子量： 489.92描述纯度储存/保存方法可溶性/溶解性In vivo(体内研究)
| 产品描述 | |
| 描述 |
PLX-4032 is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:30 mg/mL (61.23 mM)
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| 生物活性 | |
| In vivo(体内研究) |
PLX-4032 and its related analogs are highly potent inhibitors of B-Raf activity, with 3-fold selectivity for the V600E mutation over the wild-type kinase.?In preclinical models, PLX-4032 and its analogs inhibited the growth of BRAFV600E-positive melanoma cell lines both in vitro and in vivo[1].
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