E-4031 dihydrochlorideCAS号： 113559-13-0分子式： C21H27N3O3S•2HCl•2H2O分子量： 510.47描述应用纯度储存/保存方法形态外观折射率IC50Ki 数据可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
E-4031 dihydrochloride is a K+ channel blocker. Lead compound to investigate class III antiarrhythmic drugs. E-4031 dihydrochloride is a specific blocker of delayed rectifier current (I(kr)). Blocks the human ether-a-go-go-related gene (HERG) at all pulse frequencies (frequency-independent block) without significant recovery at rest.
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| 应用 |
A K+ channel blocker that spawned a class of antiarrhythmic molecules
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| 纯度 |
≥98%
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| 储存/保存方法 |
Store at 4° C
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| 形态 |
Solid
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| 基本信息 | |
| 外观 |
off-white solid
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| 折射率 |
n20D ~1.60 (Predicted)
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| IC50 |
Cardiac HERG channels: IC50 = 7.7 nM; Inactivating inward-rectifying potassium current (IK,IR) : IC50 = 10 nM; ATP sensitive K+ channel : EC5050 = 31 µM
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| Ki 数据 |
HERG: Ki= 18.7 nM (human)
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| 可溶性/溶解性 |
Soluble in water (100 mg/ml), and DMSO.
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| MDL |
MFCD00889193
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| PubChem CID |
3087190
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分子结构图
