SU5402CAS号： 215543-92-3分子式： C17H16N2O3分子量： 296.32描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
SU 5402是VEGFR2和FGFR1的多靶点抑制剂，IC50分别为20和30 nM。 |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
SU-5402；SU 5402
|
| 外观 |
light orange to dark orange powder
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| 可溶性/溶解性 |
DMSO ：29.6 mg/mL (100 mM)
|
| 生物活性 | |
| 靶点 |
VEGFR2；FGFR1；PDGFRβ
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| In vitro(体外研究) |
SU5402 inhibits VEGF-, FGF-, PDGF- dependent cell proliferation with IC50 of 0.05 μM, 2.80μM, 28.4 μM, respectively. In HUVECs, SU5416 selectively inhibits VEGF-driven mitogenesis in a dose-dependent manner with IC50 of 0.04 μM. In nasopharyngeal epithelial cells, SU5402 attenuates LMP1-mediated aerobic glycolysis, cellular transformation, cell migration, and invasion. In mouse C3H10T1/2 cells, SU 5402 diminishes the effect of FGF23 on cell differentiation.
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| In vivo(体内研究) |
In mice, SU5416 (25 mg/kg, i.p.) inhibits subcutaneous growth of a panel of tumor cell lines by inhibiting the angiogenic process associated with tumor growth.
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分子结构图
