LY223982CAS号： 117423-74-2分子式： C30H30O7分子量： 502.6描述应用纯度储存/保存方法形态别名密度沸点折射率PK值Ki 数据可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
LY223982 is a potent P2Y7 (BLT1) receptor antagonist and benzophenone dicarboxylic acid derivative. It inhibits the specific binding of radiolabeled-LTB4 to isolated human neutrophils with an IC50 value of 13.2 nM. LY223982 inhibits the LTB4-induced aggregation of guinea pig and human neutrophils with IC50 values of 74 and 100 nM, respectively.
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| 应用 |
A potent P2Y7 (BLT1) receptor antagonist
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| 纯度 |
≥98%
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| 储存/保存方法 |
Store at -20° C
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| 形态 |
Solid
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| 基本信息 | |
| 别名 |
Benzenepropanoicacid, 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexenyl]oxy]- (9CI);Benzenepropanoic acid,5-(3-carboxybenzoyl)-2-[[6-(4-methoxyphenyl)-5-hexenyl]oxy]-, (E)-; CGS 23131;LY 223982; SKF 107324
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| 密度 |
~1.2 g/cm3 (Predicted)
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| 沸点 |
~753.8° C at 760 mmHg (Predicted)
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| 折射率 |
n20D 1.61 (Predicted)
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| PK值 |
pKa: 3.81 (Predicted)
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| Ki 数据 |
P2Y7: Ki= 7.8 nM (human); Leukotriene B4 receptor: Ki= 11 nM (human)
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| 可溶性/溶解性 |
Soluble in 1:1 DMF:PBS (pH 7.2) (0.5 mg/ml), ethanol (0.1 mg/ml), DMF (20 mg/ml), and DMSO (~20 mg/ml).
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| MDL |
MFCD00876442
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| PubChem CID |
6444688
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