GW 833972A

GW 833972ACAS号: 1092502-33-4分子式: C44H57NO8分子量: 727.93描述储存/保存方法可溶性/溶解性In vitro(体外研究)In vivo(体内研究)

产品描述
描述
GW 833972A is a selective CB2 receptor agonist.GW 833972A has an inhibitory effect on induced neural depolarization and on citric acid-induced cough in an animal model.
储存/保存方法
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性
DMSO:27.5 mg/mL (37.78 mM)
生物活性
In vitro(体外研究)
GW 833972A (0.3-300 μ M; 10 min) inhibited Capsaicin induced Depolarization of human and guinea pigs, and also inhibited Prostaglandin E (2) and hypertonic saline induced Depolarization of isolated guinea pig Vagus nerve nerve.[1]
In vivo(体内研究)
GW 833972A (30 mg/kg, 2 mL/kg; intraperitoneal injection; single dose, injected 30 minutes before the start of the experiment) can inhibit conscious cough symptoms induced by citric acid in guinea pigs. It also inhibits the main bronchial Blood protein exudation caused by Capsaicin.[1]