BRD73954CAS号： 1440209-96-0分子式： C16H16N2O3分子量： 284.3描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
BRD-73954 is a biochemical inhibitor histone deacetylase cancer histone modification epigenetics gene regulation small molecule HDAC6 HDAC8.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
BRD-73954，BRD 73954
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| 外观 |
Powder
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| 可溶性/溶解性 |
DMSO 56 mg/mL (196.96 mM)
Ethanol 9 mg/mL warmed (31.65 mM) |
| 生物活性 | |
| 靶点 |
HDAC6 ,HDAC8
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| In vitro(体外研究) |
As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation.
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分子结构图
