PT-2385CAS号： 1672665-49-4分子式： C17H12F3NO4S分子量： 383.34描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM. |
| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO : ≥ 50 mg/mL (130.43 mM)
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| 生物活性 | |
| 靶点 |
HIF_HIF Prolyl-Hydroxylase
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| In vitro(体外研究) |
PT-2385 (PT2385) is a selective antagonist of HIF-2 over HIF-1. PT-2385 is inactive for HIF-1α.
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| In vivo(体内研究) |
PT-2385 (PT2385) inhibits expression of HIF-2α regulated genes in a dose dependent manner in vivo. Tumor is regressed with PT-2385 (3 and 10 mg/kg, p.o., b.i.d. dose) in 786-O xenograft. PT-2385 (1,3 and 10 mg/kg) also inhibits tumor-derived VEGFA protein levels. PT-2385 (10 mg/kg) treatment reduces proliferation (Ki67) and angiogenesis (CD-31).
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分子结构图
