ML385CAS号： 846557-71-9分子式： C29H25N3O4S分子量： 511.6描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
ML385 is a new-type and selective NRF2 inhibitor.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:30 mg/mL
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| 生物活性 | |
| 靶点 |
Nrf2:1.9 μM
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| In vitro(体外研究) |
ML385 reduce the NRF2 transcriptional activity in a dose-dependent manner with the maximum inhibitory concentration is 5 μM. ML385 interacts with NRF2 and affects the DNA binding activity of the NRF2-MAFG protein complex（IC50=1.9 μM）.
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| In vivo(体内研究) |
ML385 in combination with carboplatin leads to a significant reduction in tumor cell proliferation, demonstrated by fewer Ki-67 positive cells. Tumor samples treated with ML385 show a significant reduction in NRF2 protein level and its downstream target genes.
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