HLI 373CAS号： 502137-98-6分子式： C18H23N5O2•2HCl 分子量： 414.32描述应用纯度储存/保存方法形态别名折射率可溶性/溶解性PubChem CID
| 产品描述 | |
| 描述 |
HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) which blocks Hdm2-mediated ubiquitylation, proteasomal degradation of p53 and activates p53-dependent transcription. Additionally induces apoptosis in several tumor cell lines (LOX-IMVI, A549 and HT1080) expressing wild-type p53.
|
| 应用 |
An apoptosis inducer and inhibitor of Hdm2 ubiquitin ligase
|
| 纯度 |
≥98%
|
| 储存/保存方法 |
Store at 4° C
|
| 形态 |
Solid
|
| 基本信息 | |
| 别名 |
5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride
|
| 折射率 |
n20D ~1.64 (Predicted)
|
| 可溶性/溶解性 |
Soluble in water (100 mM), and DMSO (10 mM).
|
| PubChem CID |
72193867
|