EST73502 HClCAS号: 2307458-82-6分子式: C19H27ClF2N2O2分子量: 388.88描述储存/保存方法可溶性/溶解性靶点In vivo(体内研究)
产品描述 | |
描述 |
EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.
|
储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
|
基本信息 | |
可溶性/溶解性 |
DMSO:50 mg/mL (128.57 mM)
|
生物活性 | |
靶点 |
δ-opioid receptor:118 nM(Ki), μ-opioid receptor:64 nM(Ki)
|
In vivo(体内研究) |
In CD1 male mice, EST73502 (10-40 mg/kg; p.o.) shows a dose-response analgesic effect reaching a maximum of 64% and an EC50 of 14 mg/kg in the paw pressure test. EST73502 (5 mg/kg; i.p.) attenuated the expression of mechanical allodynia induced by PSNL, reaching a maximal effect of 56%[1].
|