Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

盐酸诺拉曲塞；二盐酸诺拉曲塞

Off-White to Pale Yellow Solid

DMSO > 10 mM

1. Hughes AN, et al. Br J Cancer. 2000 May;82(9):1519-27.

2. Rafi I, et al. J Clin Oncol. 1998 Mar;16(3):1131-41.