A-331440 dihydrochlorideCAS号: 392338-13-5(non-salt)分子式: C22H27N3O•2HCl分子量: 422.39描述储存/保存方法形态可溶性/溶解性PubChem CID
产品描述 | |
描述 |
A non-imidazole H3 histamine receptor antagonist. Presynaptic histamine H3 receptors regulate the release of histamine and other neurotransmitters, and histamine H3 receptor antagonists enhance neurotransmitter release. A-331440 is a histamine H3 receptor antagonist, which binds strongly and selectively to both human and rat histamine H(3) receptors (K(i)=25 nM). Mice on a high-fat diet (45 kcal % lard) prior to 28-day oral b.i.d. dosing for measurement of obesity-related parameters. A-331440 administered at 0.5 mg/kg had no significant effect on weight, whereas 5 mg/kg decreased weight comparably to dexfenfluramine (10 mg/kg). A-331440 administered at 15 mg/kg reduced weight to a level comparable to mice on the low-fat diet. The two higher doses reduced body fat and the highest dose also normalized an insulin tolerance test. Both data shows that the histamine H3 receptor antagonist, A-331440, has potential as an antiobesity agent.
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储存/保存方法 |
Desiccate at 4° C
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形态 |
Solid
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基本信息 | |
可溶性/溶解性 |
Soluble in water
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PubChem CID |
16078942
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