JNJ 17203212CAS号： 821768-06-3分子式： C17H15F6N5O分子量： 419.33描述应用纯度储存/保存方法形态别名密度熔点沸点折射率IC50PK值可溶性/溶解性PubChem CID
| 产品描述 | |
| 描述 |
JNJ 17203212 is a high affinity transient receptor potential vanilloid 1 (TRPV1) receptor antagonist. TRPV1 is a Capsaicin receptor that behaves as a non-selective cation channel that is mainly found in the sensory neurons, and specifically detects painful stimuli, low pH and heat. The compound has been used to investigate TRPV1 in rodent and guinea pig sensory reflexes. Research indicates that JNJ 17203212 elevates the micturition reflex threshold for activation in rodent bladder studies, and in rats weakens colonic hypersensitivity.
|
| 应用 |
A high affinity TRPV1 receptor antagonist
|
| 纯度 |
≥98%
|
| 储存/保存方法 |
Store at -20° C
|
| 形态 |
Solid
|
| 基本信息 | |
| 别名 |
4-[3-(TRIFLUOROMETHYL)-PYRIDIN-2-YL]-N-[5-(TRIFLUOROMETH YL)-PYRIDIN-2-YL]-1-PIPERAZINECARBOXAMIDE
|
| 密度 |
1.47 g/cm3 (Predicted)
|
| 熔点 |
89.4-89.8° C
|
| 沸点 |
551.32° C at 760 mmHg (Predicted)
|
| 折射率 |
n20D 1.54 (Predicted)
|
| IC50 |
Vanilloid receptor: IC50 = 16 nM (rat); VR1: IC50 = 16 nM (human); BJP: IC50 = 65 nM
|
| PK值 |
pKa: 12.62 (Predicted), pKb: 5.99 (Predicted)
|
| 可溶性/溶解性 |
Soluble in DMSO (100 mM), and ethanol (100 mM).
|
| PubChem CID |
11339118
|