Y-320CAS号： 288250-47-5分子式： C27H29ClN6O2分子量： 505.01描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
Y-320 is a new phenylpyrazoleanilide immunomodulator. |
| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
Y320；Y 320
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO ：11 mg/mL (21.78 mM)
|
| 生物活性 | |
| 靶点 |
Interleukin Related
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| In vitro(体外研究) |
Y-320 also inhibits the production of IFN-γ and TNF-α by mouse CD4 T cells stimulated with IL-15, CXCL12, and anti-CD3 mAb.
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| In vivo(体内研究) |
Y-320 (0.3-3 mg/kg p.o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys. Moreover, Y-320 shows a synergistic effect in combination with anti-TNF-α mAb on chronic-progressing CIA in mice.
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分子结构图
