SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

DMSO:125 mg/mL (271.99 mM)

TNF-α:283 nM, p38α:5 nM, p38α/β:6.11 μM, p38β:32 nM

SR-318 presents a potent and selective type-II p38α/β inhibitor,It is used as a chemical probe for targeting this particular inactive state of these two p38 isoforms.